Testosterone Replacement Therapy (TRT) is commonly used to treat hypogonadism (where the body’s sex glands make little to no sex hormones) and low testosterone levels. As with any medical treatment, it’s vital to perform rigorous research to determine its long-term effects on cardiovascular health, prostate cancer risk, and overall well-being.
To help you stay informed, we’ve compiled a list of key studies on testosterone therapy. These studies provide insights into the effects of TRT on muscle mass, heart health, cognitive function, and more. Here are some of the most recent studies:
The effects and safety of testosterone replacement therapy for men with hypogonadism (August 2024)
This comprehensive evaluation found that TRT enhances sexual function and quality of life without negatively affecting blood pressure, serum lipids, or glycemic markers. Importantly, the study found no association between TRT and an increased risk of cardiovascular events in the short to medium term.
Testosterone Therapy in Older Men: Clinical Implications of Recent Studies (July 2024)
This article examines recent placebo-controlled trials evaluating the effects of testosterone therapy in middle-aged and older men over periods of up to three years. The findings suggest that testosterone-treated men experienced significant improvements in muscle strength and power. It also found enhanced physical performance, such as improved stair-climbing ability. These results show the potential benefits of testosterone therapy in enhancing physical function in this population.
Research Finds Testosterone Therapy Safe for Heart Health (2023)
A landmark study published in 2023 followed over 5,200 men aged 45 to 80 with low testosterone levels. The results showed that testosterone replacement therapy does not elevate the risk of heart attack or stroke compared to a placebo. This finding provides reassurance for both patients and physicians, addressing previous concerns about potential cardiovascular risks associated with TRT. Dr. Prediman K. Shah, director of the Cedars-Sinai Atherosclerosis Prevention and Management Center, noted that physicians can now feel more confident in prescribing testosterone supplements to maintain normal physiological levels without significant liability.
Efficacy of Testosterone Replacement Therapy in Correcting Anemia in Men with Hypogonadism: A Randomized Clinical Trial (October 2023)
This randomized clinical trial investigates the effectiveness of testosterone replacement therapy in correcting anemia in men with hypogonadism. The findings show that a greater proportion of testosterone-treated men corrected their anemia compared to placebo-treated men.
Cardiovascular Safety of Testosterone-Replacement Therapy (June 2023)
Published in the New England Journal of Medicine, this study investigates the cardiovascular safety of testosterone-replacement therapy. The findings show that testosterone therapy was non-inferior to placebo concerning the incidence of major adverse cardiac events, suggesting that TRT does not increase cardiovascular risk in the studied population.
Whole-Body Oxidative Stress Reduction During Testosterone Therapy in Aging Men: A Randomized Placebo-Controlled Trial (May 2023)
This study examines the effects of testosterone therapy on oxidative stress levels in aging men. The results show that whole-body oxidative stress decreased during 24 weeks of testosterone replacement therapy, suggesting potential benefits in reducing oxidative damage and improving overall health.
A Systematic Review on the Latest Developments in Testosterone Therapy (August 2021)
This systematic review discusses recent innovations in testosterone treatments, focusing on various administration methods and their respective advantages and disadvantages. It underscores the importance of personalized treatment approaches, considering factors such as patient preference, how the body interacts with the treatment and potential side effects to optimize therapy outcomes.
Testosterone Replacement in Aging Men: An Evidence-Based Patient Guide (February 2021)
This guide provides an evidence-based perspective on testosterone replacement in aging men. It discusses potential benefits, such as improvements in cognitive function and mood. The guide also addresses the importance of individualized treatment plans and monitoring to ensure safety and efficacy in this population.
Hormone Balance is Vital for Long-term Health and Wellness
Hormone Balance is Vital for Long-term Health and WellnessAt Forum Health Las Colinas, we know that balancing hormones in men is just as important as it is for women. We also pride ourselves on providing personalized care to every patient. We know that your specific situation will be unique, and we treat you that way.
With thorough testing, we can determine exactly what may be causing your symptoms and provide a tailored program to help you get back to feeling your absolute best.
